Recent Publications


Targeting Peripheral Sensory Neurons to Improve Tactile-Related Phenotypes in ASD Models

Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.

Cell, August 8 2019



all Publications

Orefice LL. Outside-In: revisiting the etiology of autism spectrum disorders. Science, 2019. Oct 4; 366 (6461): 45-46

Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD. Targeting peripheral somatosensory neurons to improve tactile and behavioral phenotypes in ASD. Cell, 2019. Aug 8; 178: 867-886.

Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun R, Barondeau DP, Mootha VK. Hypoxia rescues frataxin loss by restoring iron sulfur cluster biogenesis. Cell, 2019. May 30;177(6): 1507-1521.

Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, and Kuruvilla R. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proceedings of the National Academy of Science, 2017. Jan 24;114(4):E619-E628.

Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell, 2017. Jan 12;168(1-2):295-310.

Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD. Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASD. Cell, 2016. Jul 14;166(2):299-313.

Orefice LL, Shih CC, Xu H, Xu B. Control of spine maturation and pruning through proBDNF synthesized and released in dendrites. Molecular and Cellular Neuroscience, 2016. 71;66-79.

Orefice LL, Xu B. Epigenetic Methods in Neuroscience Research. Karpova NN, editor. New York: Springer Science+Business Media; 2016. Chapter 12, Tools for analyzing the role of local protein synthesis in synaptic plasticity. 175-193p.

Orefice LL, Waterhouse EG, Partridge JG, Lalchandani RR, Vicini S, Xu B. Distinct Roles for Somatically and Dendritically Synthesized BDNF in Morphogenesis of Dendritic Spines. The Journal of Neuroscience, 2013. 33(28):11618-32.

Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, Lu B, Xu B. BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. The Journal of Neuroscience, 2012. 32(41):14318-30.

Orefice LL, Heinrichs SC. Paternal care paradoxically increases offspring seizure susceptibility in the El mouse model of epilepsy. Epilepsy & Behavior, 2008. 12(2):234-41.

Forcelli PA, Orefice LL, Heinrichs SC. Neural, endocrine and electroencephalographic hyperreactivity to human contact: A diathesis-stress model of seizure susceptibility in El mice. Brain Research, 2007. 1144: 248-56.



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